Medical Management and Treatment Guidelines

*NEW* Updated STI Treatment Guidelines (July 2021) — please see link below

Our goal is to share national and local guidelines and protocols to help you provide high-quality viral hepatitis, HIV, and sexually transmitted infection (STI) prevention and treatment care to your patients.

Viral Hepatitis

For the most current management and treatment guidelines, refer to the clinician resources at Hep Free Hawaii


Pre-Exposure Prophylaxis (PrEP) information 
The U.S. Department of Health and Human Services (DHHS) issues guidance documents for the medical management of HIV infection, including guidelines on antiretroviral treatment, prevention and treatment of opportunistic infections, post-exposure prophylaxis, and preventing perinatal transmission.

Other resources include:

National HIV Telephone Consultation Service
Offers physicians and other health care providers up-to-the-minute HIV clinical information, and individualized expert case consultation across the broad range of clinical HIV/AIDS issues.
Phone: 1-800-933-3413
Hours: 6am–5pm (PST), M–F

National Clinicians’ Post-Exposure Prophylaxis Hotline (PEPline)
Offers clinicians up-to-the-minute advice on managing occupational exposures (i. e., needlesticks, splashes, etc.) to HIV, hepatitis, and other blood-borne pathogens.
Phone: 1-888-448-4911
Hours: 24 hours / 7 days a week

Additional local information on HIV Medical Case Management and Medication Services

Sexually Transmitted Infections (STIs)

Medical Advisories and News Releases
Revised CDC Gonorrhea Treatment Guidelines – March 17, 2021
Hawaiʻi Department of Health Reports Rise in Syphilis Cases Among Women and Newborns Over the Past Four Years – October 21, 2020
Congenital Syphilis is Increasing Statewide – August 18, 2020

*NEW* Hawaiʻi STD Screening Recommendations, 2021
CDC Laboratory recommendations for detecting Chlamydia trachomatis and Neisseria gonorrhoeae, 2014

*NEW* Hawaiʻi STD Treatment Guidelines, 2021
*NEW* CDC STD Treatment Guidelines, 2021
Update to CDC’s Treatment Guidelines for Gonococcal Infection, 2020
Download the free CDC STD Tx Guide app available for Apple devices and Android devices

Evaluation and Management
Hawaiʻi DOH Guidelines for Neisseria gonorrhoeae Infection Treatment, Management, and Reporting, 2020
Evaluating Patients for Primary Syphilis
Evaluating Patients for Secondary Syphilis
Prenatal Syphilis Screening, Staging, Treatment, and Monitoring for CS Prevention
Congenital Syphilis Medical Management

Hawaiʻi DOH STI Information Line
Healthcare providers with questions about STIs can call our STI Information Line at (808) 733-9281:
Press Option 1 to report STIs, obtain clinical history on a patient, or refer a patient and/or their sex partner for intervention services.
Press Option 2 to request a clinical consultation with a DOH STI/HIV Clinic provider.

Expedited Partner Therapy (EPT)
EPT is the clinical practice of treating the sexual partners of a patient diagnosed with a sexually-transmitted infection (STI) by having the patient convey medication or a prescription to his or her partners. Hawaiʻi’s EPT law allows health care providers to offer this treatment to partners of their patients without medical examination of those partners.

EPT is not recommended as a first-line response to diagnosis of a treatable STI in patients.  While the most effective treatment of patients’ infections will include proper treatment of their recent and current sexual partners, the best practice is for partners of medically evaluated patients to obtain prompt medical evaluation themselves. This is important for ensuring good health in the partners, preventing reinfection of the patient already diagnosed and treated, and reducing the further spread of unrecognized infections in our community.

The Hawaiʻi law permits EPT treatment for all conditions recommended for EPT treatment by the Centers for Disease Control and Prevention (CDC). CDC EPT recommendations and treatment guidelines are available online.

DOH EPT Partner Information Sheets
Chlamydia Infection
Gonorrhea Infection (updated 2020)
Chlamydia and Gonorrhea Dual Infection (updated 2020)